Applied Pharmacology: Characterization of Mechanisms Involved in Pain, Inflammation and Cancer
CONTENTS
Foreword
Research Structures
Energy, Environment, and Biodiversity
- Metallic Materials Engineering
- Solar Energy
- Biodiversity and Ecosystems in Fields and Forests of the Atlantic Forest
- Economic, Human, and Environmental Development
- Primatology
- Genetics, Evolution, Ecology, and Conservation of Carnivores
- Oleochemistry: Processes and Products
- Technologies to Mitigate Environmental Impacts
- Ichthyology
- Ornithology
- The Center for Wind Energy
Humanities and Ethics
- Fundamental Rights
- Theological and Ethical Anthropology
- The Political Authoritarianism and Press in Contemporary Brazil
- Christology within the Contemporary Latin American Context
- Law and Bioethics
- Clinical Bioethics
- Ecclesiology and Emergent Problems
- Analytic Epistemology
- Ethics, Contemporaneity, and Deconstruction: The Philosophical Criticism of Violence
- Immigration, Towns, and Foreigners Narratives of Brazil (1864–1964)
- Criminal Procedure and Democratic Rule of Law
Culture and Education
- Southern Writers Collection
- Architecture and Heritage
- Culture, Subjectivity, and Formative Policies
- Between the Memories and Stories of Schools at Rio Grande do Sul: From the Deutscher Hilfsverein to Farroupilha School (1858-2008)
- Enunciation and Discourse
- Education for Health and Inclusive Education
- Teaching of Physics
- Format Y: Formation in Mathematics for Generation Y
- History of Literature: The Investigation and Diffusion of Sources
- Reading Literature: The School and Other Social Agencies
- Chemical Education
- Relationship between the Nature of Science and Science Education
- Literature, History, and Theories on the Imaginary
- Training of Professors, Licentiates, and Pedagogical Practices
Society and Development
- Companies and Organizations
- Law and Economy
- Study and Research on Violence
- Family, Social Work, and Health
- Architecture and Industrialization
- Agribusiness
- Social Well-being Economics
- Applied Mathematics
- Class Action Lawsuits
- Psychology and Social Policies: Memory, History, and Production of the Present Time
- Inter-organizational Relationships and Systemic Competitiveness
- Parties, Elections, and Political Communication
- Fundamental Principles of Tax Law
- Social Demands and Policies
Information and Communication Technology
- Wireless, Wired, and Optic Communications
- Organizational Communication
- Strategy and Innovation
- Hardware Project Support
- Computing Molecular Biophysics – The Modeling and Simulation of Biosystems
- Technological Development in Telehealth
- Resource Management and Virtualization
- The Management and Governance of Information Technology
- International News at the Global Village
- Communication Science
- Ubiquity and Technological Convergences in Communication
- Aerospace Research
- The Performance Evaluation Group
- The Group on Systems, Signals, and Computing
Biology and Health
- Cancer and Other Pathologies of the Oral and Maxillofacial Region
- Memory
- Molecular and Functional Biology
- Cardiometabolic Risk, Aging, and Nutrition
- Health Education and Work
- Structural Biochemistry
- Pediatric Respirology
- Applied Pharmacology: Characterization of Mechanisms Involved in Pain, Inflammation and Cancer
- Immunology and Immunodiagnostics
- Nephrology
- Neurosciences
- Orthodontics
- The Promotion of Health in Longevity
- Olympic Studies and Health Sciences
- Nerve Regeneration
- Intensive Neonatal Medicine and Congenital Infections
- Aerospace Pharmacy
- Medical Imaging
- Pulmonology
- Orofacial Pain and Temporomandibular Disorders
- Metabolic Transformations of Purines of Biological Importance
- The Study of Parasitosis, Biochemical Parameters, and Hematological Parameters Associated with Aging
- Aerospace Science
- Bioethics and Ethics Applied to Animals
- Pharmacovigilance
- Evaluation and Intervention in the Life Cycle
- Surgery for Obesity and Metabolic Syndrome
- Modification of Lifestyle and Cardiovascular Risk
- Nanostructures and Nanoscopy
- Clinical and Experimental Neuropsychology
- Psychology of Occupational Health
- Memory and Neurodegeneration
- Epidemiology, Neurology, and Immunology
- Chemistry of Natural Products
- Health Economics
Research Structures and Researchers
- RESEARCH STRUCTURES AND RESEARCHERS
- Business School: Management, Accounting and Economics (FACE)
- School of Architecture and Urbanism (FAU)
- School of Biosciences (FABIO)
- School of Aeronautical Sciences (FACA)
- School of Social Communication (FAMECOS)
- Law School (FADIR)
- School of Education (FACED)
- School of Physical Education and Sport Science (FEFID)
- School of Nursing, Nutrition and Physiotherapy (FAENFI)
- School of Engineering (FENG)
- School of Pharmacy (FFARM)
- School of Philosophy and Human Sciences (FFCH)
- School of Physics (FAFIS)
- School of Computer Science (FACIN)
- School of Letters: Languages, Linguistics and Literature (FALE)
- School of Mathematics (FAMAT)
- School of Medicine (FAMED)
- School of Dentistry (FO)
- School of Psychology (FAPSI)
- School of Chemistry (FAQUI)
- School of Social Work (FSS)
- School of Theology (FATEO)
- Institute of Bioethics (IB)
- Institute of Geriatrics and Gerontology (IGG)
- Institute of Research and Development (IDÉIA)
- Institute of Biomedical Research (IPB)
- Institute of Toxicology and Pharmacology (INTOX)
- Institute of the Brain (InsCer)
- Institute of Environment and Natural Resources (IMA)
- Museum of Sciences and Technology (MCT)
Focus on chronic diseases and pruritus
The Research Group on Applied Pharmacology: Characterization of Mechanisms Involved in Pain, Inflammation, and Cancer, associated with the Institute of Toxicology and Pharmacology of PUCRS, organizes its actions based on five research areas. Currently, the team, co-led by Professors Maria Martha Campos and Fernanda Bueno Morrone, concentrates its activities on the study of pruritus and other inflammation-related diseases, including cancer.
One of the goals of the researchers is to identify new alternatives to treat different types of pain caused by chronic diseases, such as fibromyalgia and neuropathies resulting from diabetes, chemotherapy, or trauma. Understanding the process of the diseases will allow the researchers to identify specific pharmaceutical agents or possible combinations of medications to mitigate the effects of the pain, mainly in cases in which the traditional prescriptions are ineffective. This study is aligned with Ordinance 1,284 of the Ministry of Health, released in 2010, encouraging the expansion of research on non-infectious chronic diseases. The document highlights the need for Brazil to invest in innovative, low-cost therapies with fewer side effects for ailments such as diabetes, depression, psoriasis, and lupus.
The study of itching of different origins is an emerging topic in science, and the Research Group on Applied Pharmacology is one of the leaders in this matter in Brazil. In 2011, the researchers published an article in the journal PAIN, which is the international reference on the area. Currently, the projects in this Group involve the following: a) evaluation of intracellular signaling pathways involved in itching; b) studying alterations in the expression of receptors at the spinal and supraspinal levels; and c) studies on toxinology focused on the anti-itching effects of toxins from the Brazilian spider Phoneutria nigriventer., The last project is supported by the Brazilian Coordination for the Improvement of Higher Education Personnel (Capes), and in partnership with the Federal University of Minas Gerais. Other ongoing projects seek to use these toxins to treat diseases such as cancer and hemorrhagic cystitis.